Search results for "Lack of efficacy"
showing 3 items of 3 documents
Strategies for Active Learning to Improve Student Learning and Attitudes Towards Physics
2021
Over the last several years, active learning methods and strategies have received considerable attention from the educational community and are commonly presented in the related literature as a credible solution to the reported lack of efficacy of more “traditional” educative approaches. Research has shown that a possible factor is the strongly contextualized nature of active learning that focuses on the interdependence of situation and cognition. In this paper, we report the results of a Symposium with different contributions in the field of research on active learning. We start with a system analysis of the mental processes involved in learning physics which explains how active learning i…
Lack of efficacy of mitoxantrone in primary progressive Multiple Sclerosis irrespective of pharmacogenetic factors: A multi-center, retrospective ana…
2014
Abstract Background Mitoxantrone is used on an off-label basis in primary progressive MS (PPMS). ABC -transporter-genotypes are associated with therapeutic response in relapsing/secondary progressive MS (RP/SPMS). Objective To evaluate potential pharmacogenetic response markers for mitoxantrone in PPMS. Methods 41 mitoxantrone-treated PPMS-patients, 155 mitoxantrone-treated RP/SPMS-patients and 43 PPMS-controls were retrospectively assessed for clinical therapy-response and in correlation with four single-nucleotide-polymorphisms in ABCB1 - and ABCG2 -genes. Results 53.7% PPMS-patients were mitoxantrone-responders, in comparison to 78.1% of RP/SPMS-patients (p = 0.039). There was no associa…
Safety Related Behaviors and Law Adherence of Shared E-Scooter Riders in Germany
2021
Shared e-scooters, whose supply and coverage keeps increasing in many cities around the globe, are rapidly changing mobility in urban road environments. As rising injury rates have been observed alongside this new form of mobility, researchers are investigating potential factors that relate to safe/unsafe e-scooter use. In Germany, e-scooter sharing platforms were only recently permitted in the middle of 2019, and their number has increased steadily since then. The aim of this study was to assess key factors that relate to their safe use, through a direct observation of e-scooters conducted at three observation sites around Berlin. Helmet use, dual use, type of infrastructure use, and trave…